377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan
Tel +81-72-366-0221
Fax +81-72-366-0245
E-mail seika2@med.kindai.ac.jp
Assistant Professor：Masahiko Honda
Assistant Professor：Ryoichi Sugisawa
Education
| 2017 | Ph.D., Laboratory of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo (Supervisor: Dr. Toru Miyazaki) |
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| 2013 | BVetMed., School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University |
Work experience
| 2023-present | Assistant Professor, Department of Biochemistry, Kindai University Faculty of Medicine |
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| 2017-2023 | Research Fellow, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland (Prof. Andrew G Bowie lab) |
| 2017 | Project Assistant Professor, Faculty of Medicine, The University of Tokyo |
Selected publications
Sugisawa, R.,Shanahan, KA, Davis, GM, Davey, GP, Bowie, AG. SARM1 regulates pro-inflammatory cytokine expression in human monocytes by NADase-dependent and -independent mechanisms. iScience 27 (6) 109940 (2024). DOI: 10.1016/j.isci.2024.109940
Doran, CG., Sugisawa, R., Carty, M., Roche, F., Fergus, C., Hokamp, K., Kelly, VP. and Bowie, AG. CRISPR/Cas9-mediated SARM1 knockout and epitope tagged mice reveal that SARM1 does not regulate nuclear transcription, but is expressed in macrophages. JBC. 16;297(6):101417. (2021) DOI: 10.1016/j.jbc.2021.101417
Carty, M., Kearney, J., Shanahan, KA., Hams, E., Sugisawa, R., Connolly, D., Doran, CG., Muñoz-Wolf, N., Gürtler, C., Fitzgerald, KA., Lavelle, EC., Fallon, PG. and Bowie, AG. Cell survival and cytokine release after inflammasome activation is regulated by the Toll-IL-1R protein SARM. Immunity. 18;50(6), 1412-1424. (2019) DOI: 10.1016/j.immuni.2019.04.005
Sugisawa, R., Komatsu, G., Hiramoto, E., Takeda, N., Yamamura, K., Arai, S. and Miyazaki, T. Independent modes of disease repair by AIM protein distinguished in AIM-felinized mice. Sci Rep. 8, 13157. (2018) DOI: 10.1038/s41598-018-31580-6
Sugisawa, R., Hiramoto, E., Matsuoka, S., Iwai, S., Takai, R., Yamazaki, T., Mori, N., Okada, Y., Takeda, N., Yamamura, K., Arai, T., Arai, S. and Miyazaki, T. Impact of feline AIM on the susceptibility of cats to renal disease. Sci Rep. 6: 35251. (2016) DOI: 10.1038/srep35251
Arai, S., Kitada, K., Yamazaki, T., Takai, R., Zhang, X., Tsugawa, Y., Sugisawa, R., Matsumoto, A., Mori, M., Yoshihara, Y., Doi, K., Maehara, N., Kusunoki, S., Takahata, A., Noiri, E., Suzuki, Y., Yahagi, N., Nishiyama, A., Gunaratnam, L., Takano, T. and Miyazaki, T. Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and
ameliorates acute kidney injury in mice. Nat Med. 22: 183-193. (2016) DOI: 10.1038/nm.4012
