Member - Department of Biochemistry Kindai University Faculty of Medicine

Professor：Hitoshi Okada

Education

Work experience

Associate Professor：Takeshi Ueda

Education

Work experience

Selected publications

Ueda T, Nakata Y, Yamasaki N, Oda H, Sentani K, Kanai A, Onishi N, Ikeda K, Sera Y, Honda Z, Tanaka K, Sata M, Ogawa S, Yasui W, Saya H, Takita J, Honda H. ALK R1275Q perturbs extracellular matrix, enhances cell invasion, and leads to the development of neuroblastoma in cooperation with MYCN. Oncogene 2016

Ueda T, Nakata Y, Nagamachi A, Yamasaki N, Kanai A, Sera Y, Sasaki M, Matsui H, Honda Z, Oda H, Wolff L, Inaba T, Honda H. Propagation of trimethylated H3K27 regulated by polycomb protein EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression. Proc Natl Acad Sci U S A 2016

Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y, Ikeda K Konuma T, Oda H, Wolff L, Honda Z, Wu X, Helin K, Iwama A, Suda T, Inaba T, Honda H. Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2. Blood 2015

Berger T, Ueda T, Arpaia E, Chio II, Shirdel EA, Jurisica I, Hamada K, You-Ten A, Haight J, Wakeham A, Cheung CC, Mak TW. Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model. Oncogene 2013

Ueda T, Sanada M, Matsui H, Yamasaki N, Honda ZI, Shih LY, Mori H, Inaba T, Ogawa S, Honda H. EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms. Leukemia 2012

Ueda T, Sasaki M, Elia AJ, Chio II, Hamada K, Fukunaga R, Mak TW. Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development. Proc Natl Acad Sci U S A 2010

Ueda T, Watanabe-Fukunaga R, Ogawa H, Fukuyama H, Higashi Y, Nagata S, Fukunaga R. Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis. Genes Cells 2007

Ueda T, Watanabe-Fukunaga R, Fukuyama H, Nagata S, Fukunaga R. Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development. Mol Cell Biol 2004

Assistant Professor：Akiyoshi Komuro

Education

Work experience

Selected publications

Komuro A, Raja E, Iwata C, Soda M, Isogaya K, InoY, Todo T, Aburatani H, Suzuki H, Ranjit M, Morikawa M, Natsume A, Mukasa A, Saito N, Okada H, Mano H, Miyazono K, Koinuma D.: Identification of a novel fusion gene HMGA2-EGFR in glioblastoma. International Journal of Cancer. 142(8) 1627-1639. (2018)

Raja E, Komuro A, Tanabe R, Sakai S, Ino Y, Saito N, Todo T, Morikawa M, Aburatani H, Koinuma D, Iwata C, Miyazono K.: Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells. Oncogene. 36(35):4963-497. (2017)

Tong KI, Ota K, Komuro A, Ueda T, Ito A, Koch AC, Okada H.: Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model. Cell death & disease. 7(10):e2401. (2016)

Kawabata KC, Ehata S, Komuro A, Takeuchi K, Miyazono K.: TGF-b-induced apoptosis of B-cell lymphoma Ramos cells through reduction of MS4A1/CD20.

Oncogne. 32 (16), 2096-2106. (2013)

Johansson E, Komuro A, Iwata C, Hagiwara A, Fuse Y, Watanabe A, Morishita Y, Aburatani H, Funa K, Kano MR, Miyazono K: Exogenous introduction of tissue inhibitor of metalloproteinase 2 reduces accelerated growth of TGF-β-disrupted diffuse-type gastric carcinoma. Cancer Sci. 101 (11): 2398-2403. (2010)

Komuro A, Yashiro M, Iwata C, Morishita Y, Johansson E, Matsumoto Y, Watanabe A, Aburatani H, Miyoshi H, Kiyono K, Shirai Y, Suzuki IH, Hirakawa K, Kano RM, Miyazono K.: Diffuse-Type Gastric Carcinoma: Progression, Angiogenesis, and Transforming Growth Factor β Signaling. J Natl Cancer Inst. 101(8): 592-604. (2009)

Ikushima H, Komuro A, Isogaya K, Shinozaki M, Hellman U, Miyazawa K, Miyazono K.: An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signaling. EMBO J. 27: 2955-2965. (2008)

Komuro A, Imamura T, Saitoh M, Yoshida Y, Yamori T, Miyazono K, Miyazawa K.: Negative Regulation of Transforming Growth Factor-b (TGF-b) Signaling by WW Domain-containing Protein 1 (WWP1). Oncogene. 23: 6914-6923. (2004)

Assistant Professor：Hisayuki Amano

Education

Work experience

Selected publications

Amano H., Chaudhury A., Dagnino-Acosta A., Lu L., Akhanov V., Catic A., Verdin E., Johnson H., Stossi F., Sinclair D.A., Nakamaru-Ogiso E., Lopez-Berestein G., Neilson J.R., Meeker A., Finegold M., Baur J.A., and Sahin E. : Telomere dysfunction induces sirtuin repression that drives telomere-dependent disease. Cell Metabolism 2019 Mar 20. pii: S1550-4131(19)30129-9. doi: 10.1016/j.cmet.2019.03.001. [Epub ahead of print] PMID:30930169

Lee C.S., Hanna A.D., Dagnino-Acosta A., Joshi A.D., Wang H., Knoblauch M., Xia Y., Georgiou D., Xu J., Cheng L., Amano H., Reynolds C., Dong K., Lagor W., George G. Rodney G.G., Sahin E., and Hamilton S.L.. (2017): Therapeutic Intervention for a Pore-Blocking RyR1 Myopathy. Nature Communication 8: 14659

Kinugasa M.*, Amano H.*, Satomi-Kobayashi S., Miyata M., Kubo Y., Nagamatsu Y., Kurogane Y., Hirata K., Miyoshi J., Takai Y., and Rikitake Y. (2012): Necl-5/Poliovirus Receptor Interacts with VEGFR2 and Regulates VEGF-induced Angiogenesis. (*equal contribution) Circulation Research 110(5):716-26.

Amano H. and Maruyama I.N.. (2011): Aversive olfactory learning and long-term associative memory in C. elegans. Learning & Memory. 18:654–665.

Amano H., Ikeda W., Kawano S., Kajita M., Tamaru Y., Inoue N., Minami Y., Yamada A., and Takai Y. (2006): Interaction and localization of Necl-5 and PDGF receptor β at the leading edges of moving NIH3T3 cells: Implications for directional cell movement. Genes to Cells 13:269-84.

Minami Y., Ikeda W., Kajita M., Fujito T., Amano H., Tamaru Y., Kuramitsu K., Sakamoto Y., Monden M., and Takai Y. (2007): Necl-5/poliovirus receptor interacts in cis with integrin αvβ3 and regulates its clustering and focal complex formation. Journal of Biological Chemistry 282:18481-96

Amano H., Itakura K., Maruyama M., Ichisaka T., Nakagawa M., and Yamanaka S. (2006): Identification and targeted disruption of the mouse gene encoding ESG1 (PH34/ECAT2/DPPA5). BMC Developmental Biology. 28(6): 11.

Assistant Professor：Masahiko Honda

Education

Work experience

Selected publications

Honda M, Tsuchimochi H, Hitach K, Ohno S (2019): Vgll2 is required for functional adaptations of skeletal muscle induced by chronic overload. J Cell Physiol. Feb6 doi: 10.1002/jcp.28239 [Epub ahead of print]

Hudoyo AW, Hirase T, Tandelillin A, Honda M, Shirai M, Cheng J, Morisaki H, Morisaki T.(2017): Role of AMPD2 in impaired glucose tolerance induced by high fructose diet. Mol Genet Metab Rep. 13:23-29. doi: 10.1016/j.ymgmr.2017.07.006. eCollection 2017 Dec.

Honda M, Hidaka K, Fukada SI, Sugawa R, Shirai M, Ikawa M, Morisaki T.(2017): Vestigial-like 2 contributes to normal muscle fiber type distribution in mice. Sci Rep. 7(1):7168. doi: 10.1038/s41598-017-07149-0.

Honda M, Kurisaki A, Ohnuma K, Okochi H, Hamazaki TS, Asashima M.(2006): N-cadherin is a useful marker for the progenitor of cardiomyocytes differentiated from mouse ES cells in serum-free condition. Biochem Biophys Res Commun. 351(4):877-882.

Honda M, Hamazaki TS, Komazaki S, Kagechika H, Shudo K, Asashima M.(2005): RXR agonist enhances the differentiation of cardiomyocytes derived from embryonic stem cells in serum-free conditions. Biochem Biophys Res Commun. 333(4):1334-40.