メニュー

Member - Department of Biochemistry Kindai University Faculty of Medicine

  • JAPANESE
  • ENGLISH

Member

Professor:Hitoshi Okada

Education

1995 Ph.D., Graduate School of Medicine, Tohoku University
1987 M.D., School of Medicine, Tohoku University

Work experience

2015-present Scientist, Kindai University Anti-Aging Center
2014-present Professor, Department of Biochemistry
Kindai University Faculty of Medicine
2012-2014 Associate Professor, Department of Medical Biophysics, University of Toronto; Scientist, Ontario Cancer Institute; Staff Scientist, The Campbell Family Cancer Research Insitute, University Health Network
2005-2012 Assistant Professor, Department of Medical Biophysics, University of Toronto; Scientist, Ontario Cancer Institute; Staff Scientist, The Campbell Family Cancer Research Insitute, University Health Network
1999-2005 Postdoctoral Fellow, Ontario Cancer Institute (Supervisor: Dr. Tak W. Mak)
1998-1999 Postdoctoral Fellow, Columbia University (NY, U.S.A.)
1995-1998 Research Fellow, Department of Cell Biology, Japanese Foundation for Cancer Research (JFCR), (Supervisor: Dr. Tetsuo Noda)

Instructor:Takeshi Ueda

Education

2005 Ph.D.,  Graduate School of Medicine, Osaka University  (Supervisor: Dr. Shigekazu Nagata)
1996 M.D., School of Medicine, Osaka University, Japan

Work experience

2016-present Instructor, Department of Biochemistry
Kindai University Faculty of Medicine
2010-2016 Assistant Professor, The Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan
2006-2010 Postdoctoral fellow, Ontario Cancer Institute
2005-2006 Research Fellow, Japan Science and Technology Agency

Selected publications

Ueda T, Nakata Y, Yamasaki N, Oda H, Sentani K, Kanai A, Onishi N, Ikeda K, Sera Y, Honda Z, Tanaka K, Sata M, Ogawa S, Yasui W, Saya H, Takita J, Honda H. ALK R1275Q perturbs extracellular matrix, enhances cell invasion, and leads to the development of neuroblastoma in cooperation with MYCN. Oncogene 2016

Ueda T, Nakata Y, Nagamachi A, Yamasaki N, Kanai A, Sera Y, Sasaki M, Matsui H, Honda Z, Oda H, Wolff L, Inaba T, Honda H. Propagation of trimethylated H3K27 regulated by polycomb protein EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression. Proc Natl Acad Sci U S A 2016

Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y, Ikeda K Konuma T, Oda H, Wolff L, Honda Z, Wu X, Helin K, Iwama A, Suda T, Inaba T, Honda H. Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2. Blood 2015

Berger T, Ueda T, Arpaia E, Chio II, Shirdel EA, Jurisica I, Hamada K, You-Ten A, Haight J, Wakeham A, Cheung CC, Mak TW. Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model. Oncogene 2013

Ueda T, Sanada M, Matsui H, Yamasaki N, Honda ZI, Shih LY, Mori H, Inaba T, Ogawa S, Honda H. EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms. Leukemia 2012

Ueda T, Sasaki M, Elia AJ, Chio II, Hamada K, Fukunaga R, Mak TW. Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development. Proc Natl Acad Sci U S A 2010

Ueda T, Watanabe-Fukunaga R, Ogawa H, Fukuyama H, Higashi Y, Nagata S, Fukunaga R. Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis. Genes Cells 2007

Ueda T, Watanabe-Fukunaga R, Fukuyama H, Nagata S, Fukunaga R. Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development. Mol Cell Biol 2004

Assistant Professor:Kazushige Ota

Education

2010 Ph.D., Graduate school of Medicine, Tohoku University (Supervisor: Dr. Kazuhiko Igarashi)
2003 M.D., School of Medicine, Tohoku University, Japan

Work experience

2014-present Assistant Professor, Department of Biochemistry
Kindai University Faculty of Medicine
2012-2014 Postdoctoral Fellow, Ontario Cancer Institute (Supervisor: Dr. H Okada)
2010-2012 Assistant Professor, Department of Biochemistry, Grasuate School of Medicine, Tohoku University, Japan

Selected publications

Kazushige Ota, Andrey Brydun, Ari Itoh-Nakadai, Jiying Sun, Kazuhiko Igarashi. Bach1 deficiency and accompanying overexpression of heme oxygenase-1 do not influence aging or tumorigenesis in mice. Oxidative Medicine and Cellular Longevity 757901, 2014

Hironari Nishizawa*, Kazushige Ota*, Yoshihiro Dohi, Tsuyoshi Ikura, Kazuhiko Igarashi. Bach1-mediated suppression of p53 is inhibited by p19(ARF) independently of MDM2.
Cancer Science 103(5) 897-903, 2012 (*equal contribution)

Kazushige Ota, Yoshihiro Dohi, Andrey Brydun, Ayako Nakanome , Sadayoshi Ito, Kazuhiko Igarashi. Identification of senescence-associated genes and their networks under oxidative stress by the analysis of Bach1. Antioxidant Redox Signaling 14(12) 2441-2451, 2011

Assistant Professor:Akiyoshi Komuro

Education

2007 Ph.D., Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo (Supervisor: Dr. Kohei Miyazono)
2003 M.S., Department of Biological Science, Graduate School of Bioscience, Tokyo Institute of Technology, Japan
2001 BSc., School of Bioscience, Tokyo Institute of Technology, Japan

Work experience

2015-present Assistant Professor, Department of Biochemistry
Kindai University Faculty of Medicine
2010-2015 Project Researcher, Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Japan
2008-2010 Postdoctoral Fellow, Helen Diller Family Comprehensive Cancer Center, Department of Neurological Surgery, UCSF 
(Supervisor: Dr. Gabriele Bergers)

Selected publications

Johansson E., Komuro A., Iwata C., Hagiwara A., Fuse Y., Watanabe A., Morishita Y., Aburatani H., Funa K., Kano MR., Miyazono K. (2010): Exogenous introduction of tissue inhibitor of metalloproteinase 2 reduces accelerated growth of TGF-β-disrupted diffuse-type gastric carcinoma. Cancer Sci. 101 (11): 2398-2403

Komuro A., Yashiro M., Iwata C., Morishita Y., Johansson E., Matsumoto Y., Watanabe A., Aburatani H., Miyoshi H., Kiyono K., Shirai Y., Suzuki I. H., Hirakawa K., Kano R. M. and Miyazono K. (2009): Diffuse-Type Gastric Carcinoma: Progression, Angiogenesis, and Transforming Growth Factor β Signaling. J Natl Cancer Inst. 101(8): 592-604

Ikushima H., Komuro A., Isogaya K., Shinozaki M., Hellman U., Miyazawa K. and Miyazono K. (2008): An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signaling. EMBO J. 27: 2955-2965

Komuro A., Imamura T., Saitoh M., Yoshida Y., Yamori T., Miyazono K. and Miyazawa K. (2004): Negative Regulation of Transforming Growth Factor-β (TGF-β) Signaling by WW Domain-containing Protein 1 (WWP1). Oncogene. 23: 6914-6923

Assistant Professor:Hisayuki Amano

Education

2009 Ph.D., Graduate school of Medicine, Osaka University (Supervisor: Dr. Yoshimi Takai)
2005 M.S., Nara Institute of Science and Technology Graduate School of Science (Supervisor: Dr. Shinya Yamanaka)
2003 BSc, Department of Life Science and Biotechnology, Kansai University

Work experience

2017-present Assistant Professor, Department of Biochemistry
Kindai University Faculty of Medicine
2012-2017 Postdoctoral Associate, Huffington Center on Aging and Department of Physiology and Biophysics, Baylor College of Medicine
2009-2012 Postdoctoral fellow, Okinawa Instutite of Science and Technology Graduate University

Selected publications

Lee C.S., Hanna A.D., Dagnino-Acosta A., Joshi A.D., Wang H., Knoblauch M., Xia Y., Georgiou D., Xu J., Cheng L., Amano H., Reynolds C., Dong K., Lagor W., George G. Rodney G.G., Sahin E., and Hamilton S.L.. (2017): Therapeutic Intervention for a Pore-Blocking RyR1 Myopathy. Nature Communication 8: 14659

Kinugasa M.*, Amano H.*, Satomi-Kobayashi S., Miyata M., Kubo Y., Nagamatsu Y., Kurogane Y., Hirata K., Miyoshi J., Takai Y., and Rikitake Y. (2012): Necl-5/Poliovirus Receptor Interacts with VEGFR2 and Regulates VEGF-induced Angiogenesis. (*equal contribution) Circulation Research 110(5):716-26.

Amano H. and Maruyama I.N.. (2011): Aversive olfactory learning and long-term associative memory in C. elegans. Learning & Memory. 18:654–665.

Amano H., Ikeda W., Kawano S., Kajita M., Tamaru Y., Inoue N., Minami Y., Yamada A., and Takai Y. (2006): Interaction and localization of Necl-5 and PDGF receptor β at the leading edges of moving NIH3T3 cells: Implications for directional cell movement. Genes to Cells 13:269-84.

Minami Y., Ikeda W., Kajita M., Fujito T., Amano H., Tamaru Y., Kuramitsu K., Sakamoto Y., Monden M., and Takai Y. (2007): Necl-5/poliovirus receptor interacts in cis with integrin αvβ3 and regulates its clustering and focal complex formation. Journal of Biological Chemistry 282:18481-96

Amano H., Itakura K., Maruyama M., Ichisaka T., Nakagawa M., and Yamanaka S. (2006): Identification and targeted disruption of the mouse gene encoding ESG1 (PH34/ECAT2/DPPA5). BMC Developmental Biology. 28(6): 11.