377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan
Tel +81-72-366-0221
Fax +81-72-366-0245
E-mail seika2@med.kindai.ac.jp
Professor：Hitoshi Okada
Education
| 1995 | Ph.D., Graduate School of Medicine, Tohoku University |
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| 1987 | M.D., School of Medicine, Tohoku University |
Work experience
| 2024-present | Director, Kindai University Life Science Research Institute |
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| 2015-present | Scientist, Kindai University Anti-Aging Center |
| 2014-present | Professor, Department of Biochemistry Kindai University Faculty of Medicine |
| 2012-2014 | Associate Professor, Department of Medical Biophysics, University of Toronto; Scientist, Ontario Cancer Institute; Staff Scientist, The Campbell Family Cancer Research Insitute, University Health Network |
| 2005-2012 | Assistant Professor, Department of Medical Biophysics, University of Toronto; Scientist, Ontario Cancer Institute; Staff Scientist, The Campbell Family Cancer Research Insitute, University Health Network |
| 1999-2005 | Postdoctoral Fellow, Ontario Cancer Institute (Supervisor: Dr. Tak W. Mak) |
| 1998-1999 | Postdoctoral Fellow, Columbia University (NY, U.S.A.) |
| 1995-1998 | Research Fellow, Department of Cell Biology, Japanese Foundation for Cancer Research (JFCR), (Supervisor: Dr. Tetsuo Noda) |
Associate Professor：Takeshi Ueda
Education
| 2005 | Ph.D., Graduate School of Medicine, Osaka University (Supervisor： Dr. Shigekazu Nagata) |
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| 1996 | M.D., School of Medicine, Osaka University, Japan |
Work experience
| 2019-present | Associate Professor, Department of Biochemistry Kindai University Faculty of Medicine |
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| 2016-2019 | Instructor, Department of Biochemistry Kindai University Faculty of Medicine |
| 2010-2016 | Assistant Professor, The Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan |
| 2006-2010 | Postdoctoral fellow, Ontario Cancer Institute |
| 2005-2006 | Research Fellow, Japan Science and Technology Agency |
Selected publications
Ueda T, Nakata Y, Yamasaki N, Oda H, Sentani K, Kanai A, Onishi N, Ikeda K, Sera Y, Honda Z, Tanaka K, Sata M, Ogawa S, Yasui W, Saya H, Takita J, Honda H. ALK R1275Q perturbs extracellular matrix, enhances cell invasion, and leads to the development of neuroblastoma in cooperation with MYCN. Oncogene 2016
Ueda T, Nakata Y, Nagamachi A, Yamasaki N, Kanai A, Sera Y, Sasaki M, Matsui H, Honda Z, Oda H, Wolff L, Inaba T, Honda H. Propagation of trimethylated H3K27 regulated by polycomb protein EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression. Proc Natl Acad Sci U S A 2016
Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y, Ikeda K Konuma T, Oda H, Wolff L, Honda Z, Wu X, Helin K, Iwama A, Suda T, Inaba T, Honda H. Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2. Blood 2015
Berger T, Ueda T, Arpaia E, Chio II, Shirdel EA, Jurisica I, Hamada K, You-Ten A, Haight J, Wakeham A, Cheung CC, Mak TW. Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model. Oncogene 2013
Ueda T, Sanada M, Matsui H, Yamasaki N, Honda ZI, Shih LY, Mori H, Inaba T, Ogawa S, Honda H. EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms. Leukemia 2012
Ueda T, Sasaki M, Elia AJ, Chio II, Hamada K, Fukunaga R, Mak TW. Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development. Proc Natl Acad Sci U S A 2010
Ueda T, Watanabe-Fukunaga R, Ogawa H, Fukuyama H, Higashi Y, Nagata S, Fukunaga R. Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis. Genes Cells 2007
Ueda T, Watanabe-Fukunaga R, Fukuyama H, Nagata S, Fukunaga R. Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development. Mol Cell Biol 2004
Lecturer：Akiyoshi Komuro
Education
| 2007 | Ph.D., Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo (Supervisor: Dr. Kohei Miyazono) |
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| 2003 | M.S., Department of Biological Science, Graduate School of Bioscience, Tokyo Institute of Technology, Japan |
| 2001 | BSc., School of Bioscience, Tokyo Institute of Technology, Japan |
Work experience
| 2020-present | Lecturer, Department of Biochemistry Kindai University Faculty of Medicine |
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| 2015-2020 | Assistant Professor, Department of Biochemistry Kindai University Faculty of Medicine |
| 2010-2015 | Project Researcher, Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Japan |
| 2008-2010 | Postdoctoral Fellow, Helen Diller Family Comprehensive Cancer Center, Department of Neurological Surgery, UCSF （Supervisor: Dr. Gabriele Bergers） |
Selected publications
Komuro A, Raja E, Iwata C, Soda M, Isogaya K, InoY, Todo T, Aburatani H, Suzuki H, Ranjit M, Morikawa M, Natsume A, Mukasa A, Saito N, Okada H, Mano H, Miyazono K, Koinuma D.: Identification of a novel fusion gene HMGA2-EGFR in glioblastoma. International Journal of Cancer. 142(8) 1627-1639. (2018)
Raja E, Komuro A, Tanabe R, Sakai S, Ino Y, Saito N, Todo T, Morikawa M, Aburatani H, Koinuma D, Iwata C, Miyazono K.: Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells. Oncogene. 36(35):4963-497. (2017)
Tong KI, Ota K, Komuro A, Ueda T, Ito A, Koch AC, Okada H.: Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model. Cell death & disease. 7(10):e2401. (2016)
Kawabata KC, Ehata S, Komuro A, Takeuchi K, Miyazono K.: TGF-b-induced apoptosis of B-cell lymphoma Ramos cells through reduction of MS4A1/CD20.
Oncogne. 32 (16), 2096-2106. (2013)
Johansson E, Komuro A, Iwata C, Hagiwara A, Fuse Y, Watanabe A, Morishita Y, Aburatani H, Funa K, Kano MR, Miyazono K: Exogenous introduction of tissue inhibitor of metalloproteinase 2 reduces accelerated growth of TGF-β-disrupted diffuse-type gastric carcinoma. Cancer Sci. 101 (11): 2398-2403. (2010)
Komuro A, Yashiro M, Iwata C, Morishita Y, Johansson E, Matsumoto Y, Watanabe A, Aburatani H, Miyoshi H, Kiyono K, Shirai Y, Suzuki IH, Hirakawa K, Kano RM, Miyazono K.: Diffuse-Type Gastric Carcinoma: Progression, Angiogenesis, and Transforming Growth Factor β Signaling. J Natl Cancer Inst. 101(8): 592-604. (2009)
Ikushima H, Komuro A, Isogaya K, Shinozaki M, Hellman U, Miyazawa K, Miyazono K.: An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signaling. EMBO J. 27: 2955-2965. (2008)
Komuro A, Imamura T, Saitoh M, Yoshida Y, Yamori T, Miyazono K, Miyazawa K.: Negative Regulation of Transforming Growth Factor-b (TGF-b) Signaling by WW Domain-containing Protein 1 (WWP1). Oncogene. 23: 6914-6923. (2004)
Assistant Professor：Ryoichi Sugisawa
Education
| 2017 | Ph.D., Laboratory of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo (Supervisor: Dr. Toru Miyazaki) |
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| 2013 | BVetMed., School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University |
Work experience
| 2023-present | Assistant Professor, Department of Biochemistry, Kindai University Faculty of Medicine |
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| 2017-2023 | Research Fellow, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland (Prof. Andrew G Bowie lab) |
| 2017 | Project Assistant Professor, Faculty of Medicine, The University of Tokyo |
Selected publications
Sugisawa, R.,Shanahan, KA, Davis, GM, Davey, GP, Bowie, AG. SARM1 regulates pro-inflammatory cytokine expression in human monocytes by NADase-dependent and -independent mechanisms. iScience 27 (6) 109940 (2024). DOI: 10.1016/j.isci.2024.109940
Doran, CG., Sugisawa, R., Carty, M., Roche, F., Fergus, C., Hokamp, K., Kelly, VP. and Bowie, AG. CRISPR/Cas9-mediated SARM1 knockout and epitope tagged mice reveal that SARM1 does not regulate nuclear transcription, but is expressed in macrophages. JBC. 16;297(6):101417. (2021) DOI: 10.1016/j.jbc.2021.101417
Carty, M., Kearney, J., Shanahan, KA., Hams, E., Sugisawa, R., Connolly, D., Doran, CG., Muñoz-Wolf, N., Gürtler, C., Fitzgerald, KA., Lavelle, EC., Fallon, PG. and Bowie, AG. Cell survival and cytokine release after inflammasome activation is regulated by the Toll-IL-1R protein SARM. Immunity. 18;50(6), 1412-1424. (2019) DOI: 10.1016/j.immuni.2019.04.005
Sugisawa, R., Komatsu, G., Hiramoto, E., Takeda, N., Yamamura, K., Arai, S. and Miyazaki, T. Independent modes of disease repair by AIM protein distinguished in AIM-felinized mice. Sci Rep. 8, 13157. (2018) DOI: 10.1038/s41598-018-31580-6
Sugisawa, R., Hiramoto, E., Matsuoka, S., Iwai, S., Takai, R., Yamazaki, T., Mori, N., Okada, Y., Takeda, N., Yamamura, K., Arai, T., Arai, S. and Miyazaki, T. Impact of feline AIM on the susceptibility of cats to renal disease. Sci Rep. 6: 35251. (2016) DOI: 10.1038/srep35251
Arai, S., Kitada, K., Yamazaki, T., Takai, R., Zhang, X., Tsugawa, Y., Sugisawa, R., Matsumoto, A., Mori, M., Yoshihara, Y., Doi, K., Maehara, N., Kusunoki, S., Takahata, A., Noiri, E., Suzuki, Y., Yahagi, N., Nishiyama, A., Gunaratnam, L., Takano, T. and Miyazaki, T. Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and
ameliorates acute kidney injury in mice. Nat Med. 22: 183-193. (2016) DOI: 10.1038/nm.4012
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