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Member - Department of Biochemistry Kindai University Faculty of Medicine

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Member

Professor:Hitoshi Okada

Education

1995 Ph.D., Graduate School of Medicine, Tohoku University
1987 M.D., School of Medicine, Tohoku University

Work experience

2024-present Director, Kindai University Life Science Research Institute
2015-present Scientist, Kindai University Anti-Aging Center
2014-present Professor, Department of Biochemistry
Kindai University Faculty of Medicine
2012-2014 Associate Professor, Department of Medical Biophysics, University of Toronto; Scientist, Ontario Cancer Institute; Staff Scientist, The Campbell Family Cancer Research Insitute, University Health Network
2005-2012 Assistant Professor, Department of Medical Biophysics, University of Toronto; Scientist, Ontario Cancer Institute; Staff Scientist, The Campbell Family Cancer Research Insitute, University Health Network
1999-2005 Postdoctoral Fellow, Ontario Cancer Institute (Supervisor: Dr. Tak W. Mak)
1998-1999 Postdoctoral Fellow, Columbia University (NY, U.S.A.)
1995-1998 Research Fellow, Department of Cell Biology, Japanese Foundation for Cancer Research (JFCR), (Supervisor: Dr. Tetsuo Noda)

Associate Professor:Takeshi Ueda

Education

2005 Ph.D.,  Graduate School of Medicine, Osaka University  (Supervisor: Dr. Shigekazu Nagata)
1996 M.D., School of Medicine, Osaka University, Japan

Work experience

2019-present Associate Professor, Department of Biochemistry
Kindai University Faculty of Medicine
2016-2019 Instructor, Department of Biochemistry
Kindai University Faculty of Medicine
2010-2016 Assistant Professor, The Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan
2006-2010 Postdoctoral fellow, Ontario Cancer Institute
2005-2006 Research Fellow, Japan Science and Technology Agency

Selected publications

Ueda T, Nakata Y, Yamasaki N, Oda H, Sentani K, Kanai A, Onishi N, Ikeda K, Sera Y, Honda Z, Tanaka K, Sata M, Ogawa S, Yasui W, Saya H, Takita J, Honda H. ALK R1275Q perturbs extracellular matrix, enhances cell invasion, and leads to the development of neuroblastoma in cooperation with MYCN. Oncogene 2016

Ueda T, Nakata Y, Nagamachi A, Yamasaki N, Kanai A, Sera Y, Sasaki M, Matsui H, Honda Z, Oda H, Wolff L, Inaba T, Honda H. Propagation of trimethylated H3K27 regulated by polycomb protein EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression. Proc Natl Acad Sci U S A 2016

Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y, Ikeda K Konuma T, Oda H, Wolff L, Honda Z, Wu X, Helin K, Iwama A, Suda T, Inaba T, Honda H. Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2. Blood 2015

Berger T, Ueda T, Arpaia E, Chio II, Shirdel EA, Jurisica I, Hamada K, You-Ten A, Haight J, Wakeham A, Cheung CC, Mak TW. Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model. Oncogene 2013

Ueda T, Sanada M, Matsui H, Yamasaki N, Honda ZI, Shih LY, Mori H, Inaba T, Ogawa S, Honda H. EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms. Leukemia 2012

Ueda T, Sasaki M, Elia AJ, Chio II, Hamada K, Fukunaga R, Mak TW. Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development. Proc Natl Acad Sci U S A 2010

Ueda T, Watanabe-Fukunaga R, Ogawa H, Fukuyama H, Higashi Y, Nagata S, Fukunaga R. Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis. Genes Cells 2007

Ueda T, Watanabe-Fukunaga R, Fukuyama H, Nagata S, Fukunaga R. Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development. Mol Cell Biol 2004

Lecturer:Akiyoshi Komuro

Education

2007 Ph.D., Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo (Supervisor: Dr. Kohei Miyazono)
2003 M.S., Department of Biological Science, Graduate School of Bioscience, Tokyo Institute of Technology, Japan
2001 BSc., School of Bioscience, Tokyo Institute of Technology, Japan

Work experience

2020-present Lecturer, Department of Biochemistry
Kindai University Faculty of Medicine
2015-2020 Assistant Professor, Department of Biochemistry
Kindai University Faculty of Medicine
2010-2015 Project Researcher, Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Japan
2008-2010 Postdoctoral Fellow, Helen Diller Family Comprehensive Cancer Center, Department of Neurological Surgery, UCSF 
(Supervisor: Dr. Gabriele Bergers)

Selected publications

Komuro A, Raja E, Iwata C, Soda M, Isogaya K, InoY, Todo T, Aburatani H, Suzuki H, Ranjit M, Morikawa M, Natsume A, Mukasa A, Saito N, Okada H, Mano H, Miyazono K, Koinuma D.: Identification of a novel fusion gene HMGA2-EGFR in glioblastoma. International Journal of Cancer. 142(8) 1627-1639. (2018)

Raja E, Komuro A, Tanabe R, Sakai S, Ino Y, Saito N, Todo T, Morikawa M, Aburatani H, Koinuma D, Iwata C, Miyazono K.: Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells. Oncogene. 36(35):4963-497. (2017)

Tong KI, Ota K, Komuro A, Ueda T, Ito A, Koch AC, Okada H.: Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model. Cell death & disease. 7(10):e2401. (2016)

Kawabata KC, Ehata S, Komuro A, Takeuchi K, Miyazono K.: TGF-b-induced apoptosis of B-cell lymphoma Ramos cells through reduction of MS4A1/CD20.

Oncogne. 32 (16), 2096-2106. (2013)

Johansson E, Komuro A, Iwata C, Hagiwara A, Fuse Y, Watanabe A, Morishita Y, Aburatani H, Funa K, Kano MR, Miyazono K: Exogenous introduction of tissue inhibitor of metalloproteinase 2 reduces accelerated growth of TGF-β-disrupted diffuse-type gastric carcinoma. Cancer Sci. 101 (11): 2398-2403. (2010)

Komuro A, Yashiro M, Iwata C, Morishita Y, Johansson E, Matsumoto Y, Watanabe A, Aburatani H, Miyoshi H, Kiyono K, Shirai Y, Suzuki IH, Hirakawa K, Kano RM, Miyazono K.: Diffuse-Type Gastric Carcinoma: Progression, Angiogenesis, and Transforming Growth Factor β Signaling. J Natl Cancer Inst. 101(8): 592-604. (2009)

Ikushima H, Komuro A, Isogaya K, Shinozaki M, Hellman U, Miyazawa K, Miyazono K.: An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signaling. EMBO J. 27: 2955-2965. (2008)

Komuro A, Imamura T, Saitoh M, Yoshida Y, Yamori T, Miyazono K, Miyazawa K.: Negative Regulation of Transforming Growth Factor-b (TGF-b) Signaling by WW Domain-containing Protein 1 (WWP1). Oncogene. 23: 6914-6923. (2004)

Assistant Professor:Ryoichi Sugisawa

Education

2017 Ph.D., Laboratory of Molecular Biomedicine for Pathogenesis, Center for Disease Biology
and Integrative Medicine, Faculty of Medicine, The University of Tokyo (Supervisor: Dr. Toru
Miyazaki)
2013 BVetMed., School of Veterinary Medicine, Faculty of Veterinary Science, Nippon
Veterinary and Life Science University
   

Work experience

2023-present Assistant Professor, Department of Biochemistry, Kindai University Faculty of Medicine
2017-2023 Research Fellow, School of Biochemistry and Immunology, Trinity Biomedical
Sciences Institute, Trinity College Dublin, Ireland (Prof. Andrew G Bowie lab)
2017 Project Assistant Professor, Faculty of Medicine, The University of Tokyo
   

Selected publications

Sugisawa, R.,Shanahan, KA, Davis, GM, Davey, GP, Bowie, AG. SARM1 regulates pro-inflammatory cytokine expression in human monocytes by NADase-dependent and -independent mechanisms. iScience 27 (6) 109940 (2024). DOI: 10.1016/j.isci.2024.109940

Doran, CG., Sugisawa, R., Carty, M., Roche, F., Fergus, C., Hokamp, K., Kelly, VP. and Bowie, AG. CRISPR/Cas9-mediated SARM1 knockout and epitope tagged mice reveal that SARM1 does not regulate nuclear transcription, but is expressed in macrophages. JBC. 16;297(6):101417. (2021) DOI: 10.1016/j.jbc.2021.101417

Carty, M., Kearney, J., Shanahan, KA., Hams, E., Sugisawa, R., Connolly, D., Doran, CG., Muñoz-Wolf, N., Gürtler, C., Fitzgerald, KA., Lavelle, EC., Fallon, PG. and Bowie, AG. Cell survival and cytokine release after inflammasome activation is regulated by the Toll-IL-1R protein SARM. Immunity. 18;50(6), 1412-1424. (2019) DOI: 10.1016/j.immuni.2019.04.005

Sugisawa, R., Komatsu, G., Hiramoto, E., Takeda, N., Yamamura, K., Arai, S. and Miyazaki, T. Independent modes of disease repair by AIM protein distinguished in AIM-felinized mice. Sci Rep. 8, 13157. (2018) DOI: 10.1038/s41598-018-31580-6

Sugisawa, R., Hiramoto, E., Matsuoka, S., Iwai, S., Takai, R., Yamazaki, T., Mori, N., Okada, Y., Takeda, N., Yamamura, K., Arai, T., Arai, S. and Miyazaki, T. Impact of feline AIM on the susceptibility of cats to renal disease. Sci Rep. 6: 35251. (2016) DOI: 10.1038/srep35251

Arai, S., Kitada, K., Yamazaki, T., Takai, R., Zhang, X., Tsugawa, Y., Sugisawa, R., Matsumoto, A., Mori, M., Yoshihara, Y., Doi, K., Maehara, N., Kusunoki, S., Takahata, A., Noiri, E., Suzuki, Y., Yahagi, N., Nishiyama, A., Gunaratnam, L., Takano, T. and Miyazaki, T. Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and
ameliorates acute kidney injury in mice. Nat Med. 22: 183-193. (2016) DOI: 10.1038/nm.4012

 

 Assistant Professor:

Education

   
   
   

Work experience

   
   
   

 

 

Selected publications