Professor:Hitoshi Okada
Education
1995 | Ph.D., Graduate School of Medicine, Tohoku University |
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1987 | M.D., School of Medicine, Tohoku University |
Work experience
2015-present | Scientist, Kindai University Anti-Aging Center |
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2014-present | Professor, Department of Biochemistry Kindai University Faculty of Medicine |
2012-2014 | Associate Professor, Department of Medical Biophysics, University of Toronto; Scientist, Ontario Cancer Institute; Staff Scientist, The Campbell Family Cancer Research Insitute, University Health Network |
2005-2012 | Assistant Professor, Department of Medical Biophysics, University of Toronto; Scientist, Ontario Cancer Institute; Staff Scientist, The Campbell Family Cancer Research Insitute, University Health Network |
1999-2005 | Postdoctoral Fellow, Ontario Cancer Institute (Supervisor: Dr. Tak W. Mak) |
1998-1999 | Postdoctoral Fellow, Columbia University (NY, U.S.A.) |
1995-1998 | Research Fellow, Department of Cell Biology, Japanese Foundation for Cancer Research (JFCR), (Supervisor: Dr. Tetsuo Noda) |
Instructor:Takeshi Ueda
Education
2005 | Ph.D., Graduate School of Medicine, Osaka University (Supervisor: Dr. Shigekazu Nagata) |
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1996 | M.D., School of Medicine, Osaka University, Japan |
Work experience
2016-present | Instructor, Department of Biochemistry Kindai University Faculty of Medicine |
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2010-2016 | Assistant Professor, The Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan |
2006-2010 | Postdoctoral fellow, Ontario Cancer Institute |
2005-2006 | Research Fellow, Japan Science and Technology Agency |
Selected publications
Ueda T, Nakata Y, Yamasaki N, Oda H, Sentani K, Kanai A, Onishi N, Ikeda K, Sera Y, Honda Z, Tanaka K, Sata M, Ogawa S, Yasui W, Saya H, Takita J, Honda H. ALK R1275Q perturbs extracellular matrix, enhances cell invasion, and leads to the development of neuroblastoma in cooperation with MYCN. Oncogene 2016
Ueda T, Nakata Y, Nagamachi A, Yamasaki N, Kanai A, Sera Y, Sasaki M, Matsui H, Honda Z, Oda H, Wolff L, Inaba T, Honda H. Propagation of trimethylated H3K27 regulated by polycomb protein EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression. Proc Natl Acad Sci U S A 2016
Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y, Ikeda K Konuma T, Oda H, Wolff L, Honda Z, Wu X, Helin K, Iwama A, Suda T, Inaba T, Honda H. Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2. Blood 2015
Berger T, Ueda T, Arpaia E, Chio II, Shirdel EA, Jurisica I, Hamada K, You-Ten A, Haight J, Wakeham A, Cheung CC, Mak TW. Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model. Oncogene 2013
Ueda T, Sanada M, Matsui H, Yamasaki N, Honda ZI, Shih LY, Mori H, Inaba T, Ogawa S, Honda H. EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms. Leukemia 2012
Ueda T, Sasaki M, Elia AJ, Chio II, Hamada K, Fukunaga R, Mak TW. Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development. Proc Natl Acad Sci U S A 2010
Ueda T, Watanabe-Fukunaga R, Ogawa H, Fukuyama H, Higashi Y, Nagata S, Fukunaga R. Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis. Genes Cells 2007
Ueda T, Watanabe-Fukunaga R, Fukuyama H, Nagata S, Fukunaga R. Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development. Mol Cell Biol 2004
Assistant Professor:Kazushige Ota
Education
2010 | Ph.D., Graduate school of Medicine, Tohoku University (Supervisor: Dr. Kazuhiko Igarashi) |
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2003 | M.D., School of Medicine, Tohoku University, Japan |
Work experience
2014-present | Assistant Professor, Department of Biochemistry Kindai University Faculty of Medicine |
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2012-2014 | Postdoctoral Fellow, Ontario Cancer Institute (Supervisor: Dr. H Okada) |
2010-2012 | Assistant Professor, Department of Biochemistry, Grasuate School of Medicine, Tohoku University, Japan |
Selected publications
Kazushige Ota, Andrey Brydun, Ari Itoh-Nakadai, Jiying Sun, Kazuhiko Igarashi. Bach1 deficiency and accompanying overexpression of heme oxygenase-1 do not influence aging or tumorigenesis in mice. Oxidative Medicine and Cellular Longevity 757901, 2014
Hironari Nishizawa*, Kazushige Ota*, Yoshihiro Dohi, Tsuyoshi Ikura, Kazuhiko Igarashi. Bach1-mediated suppression of p53 is inhibited by p19(ARF) independently of MDM2.
Cancer Science 103(5) 897-903, 2012 (*equal contribution)
Kazushige Ota, Yoshihiro Dohi, Andrey Brydun, Ayako Nakanome , Sadayoshi Ito, Kazuhiko Igarashi. Identification of senescence-associated genes and their networks under oxidative stress by the analysis of Bach1. Antioxidant Redox Signaling 14(12) 2441-2451, 2011
Assistant Professor:Akiyoshi Komuro
Education
2007 | Ph.D., Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo (Supervisor: Dr. Kohei Miyazono) |
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2003 | M.S., Department of Biological Science, Graduate School of Bioscience, Tokyo Institute of Technology, Japan |
2001 | BSc., School of Bioscience, Tokyo Institute of Technology, Japan |
Work experience
2015-present | Assistant Professor, Department of Biochemistry Kindai University Faculty of Medicine |
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2010-2015 | Project Researcher, Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Japan |
2008-2010 | Postdoctoral Fellow, Helen Diller Family Comprehensive Cancer Center, Department of Neurological Surgery, UCSF (Supervisor: Dr. Gabriele Bergers) |
Selected publications
Johansson E., Komuro A., Iwata C., Hagiwara A., Fuse Y., Watanabe A., Morishita Y., Aburatani H., Funa K., Kano MR., Miyazono K. (2010): Exogenous introduction of tissue inhibitor of metalloproteinase 2 reduces accelerated growth of TGF-β-disrupted diffuse-type gastric carcinoma. Cancer Sci. 101 (11): 2398-2403
Komuro A., Yashiro M., Iwata C., Morishita Y., Johansson E., Matsumoto Y., Watanabe A., Aburatani H., Miyoshi H., Kiyono K., Shirai Y., Suzuki I. H., Hirakawa K., Kano R. M. and Miyazono K. (2009): Diffuse-Type Gastric Carcinoma: Progression, Angiogenesis, and Transforming Growth Factor β Signaling. J Natl Cancer Inst. 101(8): 592-604
Ikushima H., Komuro A., Isogaya K., Shinozaki M., Hellman U., Miyazawa K. and Miyazono K. (2008): An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signaling. EMBO J. 27: 2955-2965
Komuro A., Imamura T., Saitoh M., Yoshida Y., Yamori T., Miyazono K. and Miyazawa K. (2004): Negative Regulation of Transforming Growth Factor-β (TGF-β) Signaling by WW Domain-containing Protein 1 (WWP1). Oncogene. 23: 6914-6923
Assistant Professor:Hisayuki Amano
Education
2009 | Ph.D., Graduate school of Medicine, Osaka University (Supervisor: Dr. Yoshimi Takai) |
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2005 | M.S., Nara Institute of Science and Technology Graduate School of Science (Supervisor: Dr. Shinya Yamanaka) |
2003 | BSc, Department of Life Science and Biotechnology, Kansai University |
Work experience
2017-present | Assistant Professor, Department of Biochemistry Kindai University Faculty of Medicine |
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2012-2017 | Postdoctoral Associate, Huffington Center on Aging and Department of Physiology and Biophysics, Baylor College of Medicine |
2009-2012 | Postdoctoral fellow, Okinawa Instutite of Science and Technology Graduate University |
Selected publications
Lee C.S., Hanna A.D., Dagnino-Acosta A., Joshi A.D., Wang H., Knoblauch M., Xia Y., Georgiou D., Xu J., Cheng L., Amano H., Reynolds C., Dong K., Lagor W., George G. Rodney G.G., Sahin E., and Hamilton S.L.. (2017): Therapeutic Intervention for a Pore-Blocking RyR1 Myopathy. Nature Communication 8: 14659
Kinugasa M.*, Amano H.*, Satomi-Kobayashi S., Miyata M., Kubo Y., Nagamatsu Y., Kurogane Y., Hirata K., Miyoshi J., Takai Y., and Rikitake Y. (2012): Necl-5/Poliovirus Receptor Interacts with VEGFR2 and Regulates VEGF-induced Angiogenesis. (*equal contribution) Circulation Research 110(5):716-26.
Amano H. and Maruyama I.N.. (2011): Aversive olfactory learning and long-term associative memory in C. elegans. Learning & Memory. 18:654–665.
Amano H., Ikeda W., Kawano S., Kajita M., Tamaru Y., Inoue N., Minami Y., Yamada A., and Takai Y. (2006): Interaction and localization of Necl-5 and PDGF receptor β at the leading edges of moving NIH3T3 cells: Implications for directional cell movement. Genes to Cells 13:269-84.
Minami Y., Ikeda W., Kajita M., Fujito T., Amano H., Tamaru Y., Kuramitsu K., Sakamoto Y., Monden M., and Takai Y. (2007): Necl-5/poliovirus receptor interacts in cis with integrin αvβ3 and regulates its clustering and focal complex formation. Journal of Biological Chemistry 282:18481-96
Amano H., Itakura K., Maruyama M., Ichisaka T., Nakagawa M., and Yamanaka S. (2006): Identification and targeted disruption of the mouse gene encoding ESG1 (PH34/ECAT2/DPPA5). BMC Developmental Biology. 28(6): 11.