Member - Department of Biochemistry Kindai University Faculty of Medicine

Professor：Hitoshi Okada

Education

Work experience

Instructor：Takeshi Ueda

Education

Work experience

Selected publications

Ueda T, Nakata Y, Yamasaki N, Oda H, Sentani K, Kanai A, Onishi N, Ikeda K, Sera Y, Honda Z, Tanaka K, Sata M, Ogawa S, Yasui W, Saya H, Takita J, Honda H. ALK R1275Q perturbs extracellular matrix, enhances cell invasion, and leads to the development of neuroblastoma in cooperation with MYCN. Oncogene 2016

Ueda T, Nakata Y, Nagamachi A, Yamasaki N, Kanai A, Sera Y, Sasaki M, Matsui H, Honda Z, Oda H, Wolff L, Inaba T, Honda H. Propagation of trimethylated H3K27 regulated by polycomb protein EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression. Proc Natl Acad Sci U S A 2016

Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y, Ikeda K Konuma T, Oda H, Wolff L, Honda Z, Wu X, Helin K, Iwama A, Suda T, Inaba T, Honda H. Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2. Blood 2015

Berger T, Ueda T, Arpaia E, Chio II, Shirdel EA, Jurisica I, Hamada K, You-Ten A, Haight J, Wakeham A, Cheung CC, Mak TW. Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model. Oncogene 2013

Ueda T, Sanada M, Matsui H, Yamasaki N, Honda ZI, Shih LY, Mori H, Inaba T, Ogawa S, Honda H. EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms. Leukemia 2012

Ueda T, Sasaki M, Elia AJ, Chio II, Hamada K, Fukunaga R, Mak TW. Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development. Proc Natl Acad Sci U S A 2010

Ueda T, Watanabe-Fukunaga R, Ogawa H, Fukuyama H, Higashi Y, Nagata S, Fukunaga R. Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis. Genes Cells 2007

Ueda T, Watanabe-Fukunaga R, Fukuyama H, Nagata S, Fukunaga R. Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development. Mol Cell Biol 2004

Assistant Professor：Kazushige Ota

Education

Work experience

Selected publications

Kazushige Ota, Andrey Brydun, Ari Itoh-Nakadai, Jiying Sun, Kazuhiko Igarashi. Bach1 deficiency and accompanying overexpression of heme oxygenase-1 do not influence aging or tumorigenesis in mice. Oxidative Medicine and Cellular Longevity 757901, 2014

Hironari Nishizawa*, Kazushige Ota*, Yoshihiro Dohi, Tsuyoshi Ikura, Kazuhiko Igarashi. Bach1-mediated suppression of p53 is inhibited by p19(ARF) independently of MDM2.
Cancer Science 103(5) 897-903, 2012 (*equal contribution)

Kazushige Ota, Yoshihiro Dohi, Andrey Brydun, Ayako Nakanome , Sadayoshi Ito, Kazuhiko Igarashi. Identification of senescence-associated genes and their networks under oxidative stress by the analysis of Bach1. Antioxidant Redox Signaling 14(12) 2441-2451, 2011

Assistant Professor：Akiyoshi Komuro

Education

Work experience

Selected publications

Johansson E., Komuro A., Iwata C., Hagiwara A., Fuse Y., Watanabe A., Morishita Y., Aburatani H., Funa K., Kano MR., Miyazono K. (2010): Exogenous introduction of tissue inhibitor of metalloproteinase 2 reduces accelerated growth of TGF-β-disrupted diffuse-type gastric carcinoma. Cancer Sci. 101 (11): 2398-2403

Komuro A., Yashiro M., Iwata C., Morishita Y., Johansson E., Matsumoto Y., Watanabe A., Aburatani H., Miyoshi H., Kiyono K., Shirai Y., Suzuki I. H., Hirakawa K., Kano R. M. and Miyazono K. (2009): Diffuse-Type Gastric Carcinoma: Progression, Angiogenesis, and Transforming Growth Factor β Signaling. J Natl Cancer Inst. 101(8): 592-604

Ikushima H., Komuro A., Isogaya K., Shinozaki M., Hellman U., Miyazawa K. and Miyazono K. (2008): An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signaling. EMBO J. 27: 2955-2965

Komuro A., Imamura T., Saitoh M., Yoshida Y., Yamori T., Miyazono K. and Miyazawa K. (2004): Negative Regulation of Transforming Growth Factor-β (TGF-β) Signaling by WW Domain-containing Protein 1 (WWP1). Oncogene. 23: 6914-6923

Assistant Professor：Hisayuki Amano

Education

Work experience

Selected publications

Lee C.S., Hanna A.D., Dagnino-Acosta A., Joshi A.D., Wang H., Knoblauch M., Xia Y., Georgiou D., Xu J., Cheng L., Amano H., Reynolds C., Dong K., Lagor W., George G. Rodney G.G., Sahin E., and Hamilton S.L.. (2017): Therapeutic Intervention for a Pore-Blocking RyR1 Myopathy. Nature Communication 8: 14659

Kinugasa M.*, Amano H.*, Satomi-Kobayashi S., Miyata M., Kubo Y., Nagamatsu Y., Kurogane Y., Hirata K., Miyoshi J., Takai Y., and Rikitake Y. (2012): Necl-5/Poliovirus Receptor Interacts with VEGFR2 and Regulates VEGF-induced Angiogenesis. (*equal contribution) Circulation Research 110(5):716-26.

Amano H. and Maruyama I.N.. (2011): Aversive olfactory learning and long-term associative memory in C. elegans. Learning & Memory. 18:654–665.

Amano H., Ikeda W., Kawano S., Kajita M., Tamaru Y., Inoue N., Minami Y., Yamada A., and Takai Y. (2006): Interaction and localization of Necl-5 and PDGF receptor β at the leading edges of moving NIH3T3 cells: Implications for directional cell movement. Genes to Cells 13:269-84.

Minami Y., Ikeda W., Kajita M., Fujito T., Amano H., Tamaru Y., Kuramitsu K., Sakamoto Y., Monden M., and Takai Y. (2007): Necl-5/poliovirus receptor interacts in cis with integrin αvβ3 and regulates its clustering and focal complex formation. Journal of Biological Chemistry 282:18481-96

Amano H., Itakura K., Maruyama M., Ichisaka T., Nakagawa M., and Yamanaka S. (2006): Identification and targeted disruption of the mouse gene encoding ESG1 (PH34/ECAT2/DPPA5). BMC Developmental Biology. 28(6): 11.