Publications - Department of Biochemistry Kindai University Faculty of Medicine

2023

MYC/glutamine dependency is a therapeutic vulnerability in pancreatic cancer with deoxycytidine kinase inactivation-induced gemcitabine resistance
Dash S, Ueda T, Komuro A, Amano H, Honda M, Kawazu M, Okada H.
Molecular Cancer Research (online publication Feb 9, 2023)

https://aacrjournals.org/mcr/article/doi/10.1158/1541-7786.MCR-22-0554/716490/MYC-glutamine-dependency-is-a-therapeutic

2022

CD34+ myeloma cells with self-renewal activities are therapy-resistant and persist as MRD in cell cycle quiescence
Serizawa K, Tanaka H, Ueda T, Fukui A, Kakutani H, Taniguchi T, Inoue H, Kumode T, Taniguchi Y, Rai S, et al. International Journal of Hematology. 2022. 115. 3. 336-349

 https://link.springer.com/article/10.1007/s12185-021-03261-0

2021

UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes
Sera Y, Nakata Y, Ueda T, Yamasaki N, Koide S, Kobayashi H, Ikeda KI, Kobatake K, Iwasaki M, Oda H, Wolff L, Kanai A, Nagamachi A, Inaba T, Sotomaru Y, Ichinohe T, Koizumi M, Miyakawa Y, Honda ZI, Iwama A, Suda T, Takubo K, Honda H.
Blood 2021 Feb 18 137(7):908-922.doi: 10.1182/blood.2019001044.

 https://ashpublications.org/blood/article-abstract/137/7/908/474124/UTX-maintains-the-functional-integrity-of-the?redirectedFrom=fulltext

The KDM4B-CCAR-MED1 axis is a critical regulator of osteoblast differentiation and bone homeostasis
Sun-Ju Yi, You-Jee Jang, Hye-Jung Kim, Kyubin Lee, Hyerim Lee, Yeojin Kim, Junil Kim, Seon Young Hwang, Jin Sook Song, Hitoshi Okada, Jae-Il Park, Kyuho Kang, Kyunghwan Kim
Bone Res 9, 27 (2021). https://doi.org/10.1038/s41413-021-00145-1

 https://www.nature.com/articles/s41413-021-00145-1#citeas

Tim-3 adaptor protein Bat3 is a molecular checkpoint of T cell terminal differentiation and exhaustion
Zhu C, Dixon KO, Newcomer K, Gu G, Xiao S, Zaghouani S, Schramm MA, Wang C, Zhang H, Goto K, Christian E, Rangachari M, Rosenblatt-Rosen O, Okada H, Mak T, Singer M, Regev A, Kuchroo V.
Sci Adv 7(18): eabd2710.doi: 10.1126/sciadv.abd2710.Print 2021 Apr.

 https://advances.sciencemag.org/content/7/18/eabd2710

Copper promotes tumorigenesis by activating the PDK1-AKT oncogenic pathway in a copper transporter 1 dependent manner
Jianping Guo, Ji Cheng, Nana Zheng, Xiaomei Zhang, Xiaoming Dai, Linli Zhang, Changjiang Hu, Xueji Wu, Qiwei Jiang, Depei Wu, Hitoshi Okada, Pier Paolo Pandolfi, Wenyi Wei
Advanced Science 2021, 2004303

 https://onlinelibrary.wiley.com/doi/10.1002/advs.202004303

KDM4B promotes acute myeloid leukemia associated with AML-ETO by regulating chromatin accessibility
Takeshi Ueda*, Akinori Kanai, Akiyoshi Komuro, Hisayuki Amano, Kazushige Ota, Masahiko Honda, Masahito Kawazu, Hitoshi Okada* (*co-correspondence)
FASEB BioAdvances 29 August 2021. https://doi.org/10.1096/fba.2021-00030

 https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fba.2021-00030

2020

Expression Levels of Long Non-Coding RNAs Change in Models of Altered Muscle Activity and Muscle Mass
Hitachi K, Nakatani M, Funasaki S, Hijikata I, Maekawa M, Honda M, Tsuchida K.
Int J Mol Sci. (2020 Feb 27;21(5). pii: E1628)

 https://www.mdpi.com/1422-0067/21/5/1628

The histone demethylase JMJD2B regulates endothelial-to mesenchymal transition
Glaser SF, Heumuller AW, Tombor L, Hofmann P, Muhly-Reinholz M, Fischer A, Gunther S, Kokot KE, Okada H, Hassel D, Kumar S, Jo H, Boon, RA, Abpanalp W, John D, Boeckel JN, Dimmeler S.
Proc Natl Acad Sci U S A. 2020 Feb 25;117 (8) 4180-4187.

 https://www.pnas.org/content/117/8/4180.abstract

Kdm6a Deficiency Activates Inflammatory Pathway, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooporation with p53 Dysfunction
Kobatake K, Ikeda K, Nakata Y, Yamasaki N, Ueda T, Kanai A, Sentani K, Sera Y, Hayashi T, Koizumi M, Miyakawa Y, Inaba T, Sotomaru Y, Kaminuma O, Ichinohe T, Honda ZI, Yasui W, Horie S, Black PC, Matsubara A, Honda H.
Clin Cancer Res. 2020 Apr 15; 26(8): 2065-2079.

 https://clincancerres.aacrjournals.org/content/26/8/2065.long

Ascorbate sensitizes human osteosarcoma cells to the cytostatic effects of cisplatin
Oka N, Komuro A, Amano H, Dash S, Honda M, Ota K, Nishimura S, Ueda T, Akagi M, Okada H.
Pharmacology Research & Perspectives (2020 Aug 8; 8(4)e00632)

 https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1002/prp2.632

2019

Vgll2 Gene Alters the Gene Expression Profiling of Skeletal Muscle Subjected to Mechanical Overload
Hitachi K, Inagaki H, Kurahashi H, Okada H, Tsuchida K, Honda M.
Front. Sports Act. Living (on line 9 Oct, 2019)

https://www.frontiersin.org/articles

High Fat Diet Triggers a Reduction in Body Fat Mass in Female Mice Deficient for Utx demethylase
Ota K, Komuro A, Amano H, Kanai A, Ge K, Ueda T, Okada H.
Scientific Reports 9, 10036 (2019) (online 11 July, 2019)

https://www.nature.com/articles/s41598-019-46445-9

Telomeres and sirtuins: at the end we meet again
Amano H, Sahin E.
Molecular Cell Oncol. 6:5, DOI: 10.1080/23723556.2019.1632613 (online 7 July, 2019)

https://www.tandfonline.com/doi/full/10.1080/23723556.2019.1632613

2018

JMJD2B/KDM4B inactivation in adipose tissues accelerates obesity and systemic metabolic abnormalities
Kang C, Saso K, Ota K, Kawazu M, Ueda T, Okada H.
Genes Cells (online 3 August, 2018)

https://onlinelibrary.wiley.com/doi/abs/10.1111/gtc.12627

2017

The H3K27 demethylase, Utx, regulates adipogenesis in a differentiation stage-dependent manner
Ota K, Tong KI, Goto K, Tomida S, Komuro A, Wang Z, Nishio K, Okada H.
PLOS ONE 12(3): e0173713

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0173713

Identification of a novel fusion gene HMGA2-EGFR in glioblastoma
Komuro A, Iwata C, Soda M, Isogaya K, Ino Y, Todo T, Aburatani H, Suzuki H, Ranjit M, Natsume A, Saito N, Okada H, Mano H, Miyazono K, Daizo K.
International Journal of Cancer (online 29 November, 2017)

http://onlinelibrary.wiley.com/doi/10.1002/ijc.31179/abstract;jsessionid=99598ADF2F73AA215FCE26F51840A32D.f02t01

2016

Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model
Tong KI, Ota K, Komuro A, Ueda T, Ito A, Koch AC, Okada H.
Cell death & Disease 7(10):e2401

https://www.nature.com/articles/cddis2016298

Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse
YT Fujiwara K, Fujita Y, Kasai A, Onaka Y, Hashimoto H, Okada H, Yamashita T.
Transl Psychiatry. 6 (e766)

https://www.nature.com/articles/tp201631

Loss of survivin in intestinal epithelial progenitor cells leads to mitotic catastrophe and breakdown of gut immune homeostasis
Martini E, Wittkopf N, Gunther C, Leppkes M, Okada H, Watson AJ, Podstawa E, Backert I, Amann K, Neurath MF, Becker C.
Cell reports 14 (5), 1062-1073

http://www.sciencedirect.com/science/article/pii/S2211124716000309

2015

The Role of Histone Demethylase KDM4B in Myc Signaling in Neuroblastoma
Yang J, AlTahan AM, Hu D, Wang Y, Cheng PH, Morton CL, Qu C, Nathwani AC, Shohet JM, Fotsis T, Koster J, Versteeg R, Okada H, Harris AL, Davidoff AM.
J Natl Cancer Inst. 107 (6)

http://jnci.oxfordjournals.org/content/107/6/djv080.short

2014

Histone Lysine Demethylase and Human Diseases (review)
Okada H.
ACTA MEDICA KINKI UNIVERSITY 39 (1), 1-10

https://kindai.repo.nii.ac.jp/index.php?action=pages_view_main