Department of Biochemistry Kindai University Faculty of Medicine

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Our bodies have a variety of systems to eliminate foreign cells, organisms, and agents such as cancer cells, viruses, and bacteria. If so, how do cancer cells escape from cancer surveillance mechanisms, adapt to the microenvironment, and ensure their survival for continuous proliferation? My lab has been focused on the mechanistic understandings of how cancer cells acquire and maintain their unique biological properties with special emphasis on epigenetics. We aim to identify the regulatory mechanisms involved in multistep tumorigenesis, which will potentiate the development of novel targets for treatment, diagnosis and prevention of cancers.

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Cancer research

One out of two people will develop cancers and one in three people will die of these malignant diseases in Japan. Due to recent advance in medical technology and knowledge, the treatment efficacy of cancers has significantly improved. However, there are unsolved problems remain, which include cancers with difficulty in early diagnosis, therapeutic resistance, recurrence, and metastasis……

Epigenetics

Epigenetics refers “stably heritable phenotype resulting from changes in a chromosome without alterations in the DNA sequence” (formulated at Cold Spring Harbor meeting in 2008). The regulatory mechanisms include the modifications of DNA binding proteins (e.g. histones), DNA, RNA and noncoding RNAs……