377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan
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E-mail seika2@med.kindai.ac.jp
2024
SARM1 regulates NAD+-linked metabolism and select immune genes in macrophages
Katharine A Shanahan, Gavin M Davis, Ciara G Doran, Ryoichi Sugisawa, Gavin P Davey, Andrew G Bowie
J Biological Chemistry 3 Jan 2024. doi: 10.1016/j.jbc.2023.105620
https://www.sciencedirect.com/science/article/pii/S0021925823026492
Deoxycytidine Kinase Inactivation Enhances Gemcitabine Resistance and Sensitizes Mitochondrial Metabolism Interference in Pancreatic Cancer
Dash S, Ueda T, Komuro A, Honda M, Sugisawa R, Okada H.
Cell Death & Disease (2024) 15:131; https://doi.org/10.1038/s41419-024-06531-x
https://www.nature.com/articles/s41419-024-06531-x
ACA-28, an ERK MAPK Signaling Modulator, Exerts Anticancer Activity through ROS Induction in Melanoma and Pancreatic Cancer Cells
Takasaki T, Hamabe Y, Touchi K, Khandakar GI, Ueda T, Okada H, Sakai K, Nishio K, Tanabe G, Sugiura R
Oxidative Medicine and Cellular Longevity Volume 2024 | Article ID 7683793 | https://doi.org/10.1155/2024/7683793
https://www.hindawi.com/journals/omcl/2024/7683793/
SARM1 regulates pro-inflammatory cytokine expression in human monocytes by NADase-dependent and -independent mechanisms
Sugisawa R, Shanahan KA, Davis GM, Davey GP, Bowie AG
iScience (2024) 27 (6) 109940; DOI:10.1016/j.isci.2024.109940
https://www.cell.com/iscience/fulltext/S2589-0042(24)01162-3
Vgll2 as an integrative regulator of mitochondrial function and contractility specific to skeletal muscle
Honda M, Inoue R, Nishiyama K, Ueda T, Komuro A, Amano H, Sugisawa R, Dash S, Shirakawa J, Okada H
J Cell Physiol. 2024 Sep 17:e31436 109940; DOI:10.1002/jcp.31436
2023年
MYC/glutamine dependency is a therapeutic vulnerability in pancreatic cancer with deoxycytidine kinase inactivation-induced gemcitabine resistance
Dash S, Ueda T, Komuro A, Amano H, Honda M, Kawazu M, Okada H.
Molecular Cancer Research (2023) 21 (5): 444–457 (online publication Feb 9, 2023)
MBTD1 preserved adult hematopoietic stem cell pool size and function
Takubo K, Htun PW, Ueda T, Sera Y, Iwasaki M, Koizumi M, Shiroshita K, Kobayashi H, Haraguchi M, Watanuki S, Honda ZI, Yamasaki N, Nakamura-Ishizu A, Arai F, Motoyama N, Hatta T, Natsume T, Suda T, Honda H.
Proc Natl Acad Sci USA 2023 Aug 8; 120(32):e22036860120.doi:10.1073/pnas. 2206860120 Epub 2023 Jul. 31
https://www.pnas.org/doi/10.1073/pnas.2206860120?url_ver=Z39.88-2003&rfr_id=ori
One-carbon metabolizing enzyme ALDH1L1 influences mitochondrial metabolism through 5-aminoimidazole-4 carboxamide ribonucleotide accumulation and serine depletion, contributing to tumor suppression
Sasaki M, Yamamoto K, Ueda T, Irokawa H, Takeda K, Sekine R, Itoh F, Tanaka Y, Kuge S, Shibata N.
Sci Rep. 2023 Aug 18; 13(1):13486.doi:10.1038/s41598-023-38142-5
https://www.nature.com/articles/s41598-023-38142-5
A novel in vivo model of ureteral fibrosis induced by calcium oxalate beads in C57BL/6J mice
Watanabe M, Ando R, Sugisawa R, Sasaki N, Iwai S
Urolithiasis 51(1):119. doi: 10.1007/s00240-023-01491-x
https://link.springer.com/article/10.1007/s00240-023-01491-x
2022
CD34+ myeloma cells with self-renewal activities are therapy-resistant and persist as MRD in cell cycle quiescence
Serizawa K, Tanaka H, Ueda T, Fukui A, Kakutani H, Taniguchi T, Inoue H, Kumode T, Taniguchi Y, Rai S, et al. International Journal of Hematology. 2022. 115. 3. 336-349
https://link.springer.com/article/10.1007/s12185-021-03261-0
2021
UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes
Sera Y, Nakata Y, Ueda T, Yamasaki N, Koide S, Kobayashi H, Ikeda KI, Kobatake K, Iwasaki M, Oda H, Wolff L, Kanai A, Nagamachi A, Inaba T, Sotomaru Y, Ichinohe T, Koizumi M, Miyakawa Y, Honda ZI, Iwama A, Suda T, Takubo K, Honda H.
Blood 2021 Feb 18 137(7):908-922.doi: 10.1182/blood.2019001044.
The KDM4B-CCAR-MED1 axis is a critical regulator of osteoblast differentiation and bone homeostasis
Sun-Ju Yi, You-Jee Jang, Hye-Jung Kim, Kyubin Lee, Hyerim Lee, Yeojin Kim, Junil Kim, Seon Young Hwang, Jin Sook Song, Hitoshi Okada, Jae-Il Park, Kyuho Kang, Kyunghwan Kim
Bone Res 9, 27 (2021). https://doi.org/10.1038/s41413-021-00145-1
https://www.nature.com/articles/s41413-021-00145-1#citeas
Tim-3 adaptor protein Bat3 is a molecular checkpoint of T cell terminal differentiation and exhaustion
Zhu C, Dixon KO, Newcomer K, Gu G, Xiao S, Zaghouani S, Schramm MA, Wang C, Zhang H, Goto K, Christian E, Rangachari M, Rosenblatt-Rosen O, Okada H, Mak T, Singer M, Regev A, Kuchroo V.
Sci Adv 7(18): eabd2710.doi: 10.1126/sciadv.abd2710.Print 2021 Apr.
https://advances.sciencemag.org/content/7/18/eabd2710
Copper promotes tumorigenesis by activating the PDK1-AKT oncogenic pathway in a copper transporter 1 dependent manner
Jianping Guo, Ji Cheng, Nana Zheng, Xiaomei Zhang, Xiaoming Dai, Linli Zhang, Changjiang Hu, Xueji Wu, Qiwei Jiang, Depei Wu, Hitoshi Okada, Pier Paolo Pandolfi, Wenyi Wei
Advanced Science 2021, 2004303
https://onlinelibrary.wiley.com/doi/10.1002/advs.202004303
KDM4B promotes acute myeloid leukemia associated with AML-ETO by regulating chromatin accessibility
Takeshi Ueda*, Akinori Kanai, Akiyoshi Komuro, Hisayuki Amano, Kazushige Ota, Masahiko Honda, Masahito Kawazu, Hitoshi Okada* (*co-correspondence)
FASEB BioAdvances 29 August 2021. https://doi.org/10.1096/fba.2021-00030
https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fba.2021-00030
2020
Expression Levels of Long Non-Coding RNAs Change in Models of Altered Muscle Activity and Muscle Mass
Hitachi K, Nakatani M, Funasaki S, Hijikata I, Maekawa M, Honda M, Tsuchida K.
Int J Mol Sci. (2020 Feb 27;21(5). pii: E1628)
https://www.mdpi.com/1422-0067/21/5/1628
The histone demethylase JMJD2B regulates endothelial-to mesenchymal transition
Glaser SF, Heumuller AW, Tombor L, Hofmann P, Muhly-Reinholz M, Fischer A, Gunther S, Kokot KE, Okada H, Hassel D, Kumar S, Jo H, Boon, RA, Abpanalp W, John D, Boeckel JN, Dimmeler S.
Proc Natl Acad Sci U S A. 2020 Feb 25;117 (8) 4180-4187.
https://www.pnas.org/content/117/8/4180.abstract
Kdm6a Deficiency Activates Inflammatory Pathway, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooporation with p53 Dysfunction
Kobatake K, Ikeda K, Nakata Y, Yamasaki N, Ueda T, Kanai A, Sentani K, Sera Y, Hayashi T, Koizumi M, Miyakawa Y, Inaba T, Sotomaru Y, Kaminuma O, Ichinohe T, Honda ZI, Yasui W, Horie S, Black PC, Matsubara A, Honda H.
Clin Cancer Res. 2020 Apr 15; 26(8): 2065-2079.
https://clincancerres.aacrjournals.org/content/26/8/2065.long
Ascorbate sensitizes human osteosarcoma cells to the cytostatic effects of cisplatin
Oka N, Komuro A, Amano H, Dash S, Honda M, Ota K, Nishimura S, Ueda T, Akagi M, Okada H.
Pharmacology Research & Perspectives (2020 Aug 8; 8(4)e00632)
https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1002/prp2.632
2019
Vgll2 Gene Alters the Gene Expression Profiling of Skeletal Muscle Subjected to Mechanical Overload
Hitachi K, Inagaki H, Kurahashi H, Okada H, Tsuchida K, Honda M.
Front. Sports Act. Living (on line 9 Oct, 2019)
https://www.frontiersin.org/articles
High Fat Diet Triggers a Reduction in Body Fat Mass in Female Mice Deficient for Utx demethylase
Ota K, Komuro A, Amano H, Kanai A, Ge K, Ueda T, Okada H.
Scientific Reports 9, 10036 (2019) (online 11 July, 2019)
https://www.nature.com/articles/s41598-019-46445-9
Telomeres and sirtuins: at the end we meet again
Amano H, Sahin E.
Molecular Cell Oncol. 6:5, DOI: 10.1080/23723556.2019.1632613 (online 7 July, 2019)
https://www.tandfonline.com/doi/full/10.1080/23723556.2019.1632613
2018
JMJD2B/KDM4B inactivation in adipose tissues accelerates obesity and systemic metabolic abnormalities
Kang C, Saso K, Ota K, Kawazu M, Ueda T, Okada H.
Genes Cells (online 3 August, 2018)
2017
The H3K27 demethylase, Utx, regulates adipogenesis in a differentiation stage-dependent manner
Ota K, Tong KI, Goto K, Tomida S, Komuro A, Wang Z, Nishio K, Okada H.
PLOS ONE 12(3): e0173713
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0173713
Identification of a novel fusion gene HMGA2-EGFR in glioblastoma
Komuro A, Iwata C, Soda M, Isogaya K, Ino Y, Todo T, Aburatani H, Suzuki H, Ranjit M, Natsume A, Saito N, Okada H, Mano H, Miyazono K, Daizo K.
International Journal of Cancer (online 29 November, 2017)
2016
Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model
Tong KI, Ota K, Komuro A, Ueda T, Ito A, Koch AC, Okada H.
Cell death & Disease 7(10):e2401
https://www.nature.com/articles/cddis2016298
Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse
YT Fujiwara K, Fujita Y, Kasai A, Onaka Y, Hashimoto H, Okada H, Yamashita T.
Transl Psychiatry. 6 (e766)
https://www.nature.com/articles/tp201631
Loss of survivin in intestinal epithelial progenitor cells leads to mitotic catastrophe and breakdown of gut immune homeostasis
Martini E, Wittkopf N, Gunther C, Leppkes M, Okada H, Watson AJ, Podstawa E, Backert I, Amann K, Neurath MF, Becker C.
Cell reports 14 (5), 1062-1073
http://www.sciencedirect.com/science/article/pii/S2211124716000309
2015
The Role of Histone Demethylase KDM4B in Myc Signaling in Neuroblastoma
Yang J, AlTahan AM, Hu D, Wang Y, Cheng PH, Morton CL, Qu C, Nathwani AC, Shohet JM, Fotsis T, Koster J, Versteeg R, Okada H, Harris AL, Davidoff AM.
J Natl Cancer Inst. 107 (6)
2014
Histone Lysine Demethylase and Human Diseases (review)
Okada H.
ACTA MEDICA KINKI UNIVERSITY 39 (1), 1-10
https://kindai.repo.nii.ac.jp/index.php?action=pages_view_main
