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助教:杉澤 良一

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助教:杉澤 良一

 助教:杉澤 良一(Ryoichi Sugisawa)

学歴

2017年 東京大学大学院医学系研究科 修了、博士(医学)(宮崎徹 研究室)
2013年 日本獣医生命科学大学獣医学部 卒業
   

職歴

2023年-現在 近畿大学医学部生化学教室・助教
2017-2023年  アイルランド ダブリン大学トリニティカレッジ・博士研究員(Prof. Andrew G Bowie 研究室)
2017年 東京大学医学部・特任助教
   

代表論文

Sugisawa, R.,Shanahan, KA, Davis, GM, Davey, GP, Bowie, AG. SARM1 regulates pro-inflammatory cytokine expression in human monocytes by NADase-dependent and -independent mechanisms. iScience 27 (6) 109940 (2024). DOI: 10.1016/j.isci.2024.109940

Doran, CG., Sugisawa, R., Carty, M., Roche, F., Fergus, C., Hokamp, K., Kelly, VP. and Bowie, AG. CRISPR/Cas9-mediated SARM1 knockout and epitope tagged mice reveal that SARM1 does not regulate nuclear transcription, but is expressed in macrophages. JBC. 16;297(6):101417. (2021) DOI: 10.1016/j.jbc.2021.101417

Carty, M., Kearney, J., Shanahan, KA., Hams, E., Sugisawa, R., Connolly, D., Doran, CG., Muñoz-Wolf, N., Gürtler, C., Fitzgerald, KA., Lavelle, EC., Fallon, PG. and Bowie, AG. Cell survival and cytokine release after inflammasome activation is regulated by the Toll-IL-1R protein SARM. Immunity. 18;50(6), 1412-1424. (2019) DOI: 10.1016/j.immuni.2019.04.005

Sugisawa, R., Komatsu, G., Hiramoto, E., Takeda, N., Yamamura, K., Arai, S. and Miyazaki, T. Independent modes of disease repair by AIM protein distinguished in AIM-felinized mice. Sci Rep. 8, 13157. (2018) DOI: 10.1038/s41598-018-31580-6

Sugisawa, R., Hiramoto, E., Matsuoka, S., Iwai, S., Takai, R., Yamazaki, T., Mori, N., Okada, Y., Takeda, N., Yamamura, K., Arai, T., Arai, S. and Miyazaki, T. Impact of feline AIM on the susceptibility of cats to renal disease. Sci Rep. 6: 35251. (2016) DOI: 10.1038/srep35251

Arai, S., Kitada, K., Yamazaki, T., Takai, R., Zhang, X., Tsugawa, Y., Sugisawa, R., Matsumoto, A., Mori, M., Yoshihara, Y., Doi, K., Maehara, N., Kusunoki, S., Takahata, A., Noiri, E., Suzuki, Y., Yahagi, N., Nishiyama, A., Gunaratnam, L., Takano, T. and Miyazaki, T. Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and
ameliorates acute kidney injury in mice. Nat Med. 22: 183-193. (2016) DOI: 10.1038/nm.4012