2021 研究成果

2021 研究成果

2021年

UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes
Sera Y, Nakata Y, Ueda T, Yamasaki N, Koide S, Kobayashi H, Ikeda KI, Kobatake K, Iwasaki M, Oda H, Wolff L, Kanai A, Nagamachi A, Inaba T, Sotomaru Y, Ichinohe T, Koizumi M, Miyakawa Y, Honda ZI, Iwama A, Suda T, Takubo K, Honda H.
Blood 2021 Feb 18 137(7):908-922.doi: 10.1182/blood.2019001044.

 https://ashpublications.org/blood/article-abstract/137/7/908/474124/UTX-maintains-the-functional-integrity-of-the?redirectedFrom=fulltext

The KDM4B-CCAR-MED1 axis is a critical regulator of osteoblast differentiation and bone homeostasis
Sun-Ju Yi, You-Jee Jang, Hye-Jung Kim, Kyubin Lee, Hyerim Lee, Yeojin Kim, Junil Kim, Seon Young Hwang, Jin Sook Song, Hitoshi Okada, Jae-Il Park, Kyuho Kang, Kyunghwan Kim
Bone Res 9, 27 (2021). https://doi.org/10.1038/s41413-021-00145-1

 https://www.nature.com/articles/s41413-021-00145-1#citeas

Tim-3 adaptor protein Bat3 is a molecular checkpoint of T cell terminal differentiation and exhaustion
Zhu C, Dixon KO, Newcomer K, Gu G, Xiao S, Zaghouani S, Schramm MA, Wang C, Zhang H, Goto K, Christian E, Rangachari M, Rosenblatt-Rosen O, Okada H, Mak T, Singer M, Regev A, Kuchroo V.
Sci Adv 7(18): eabd2710.doi: 10.1126/sciadv.abd2710.Print 2021 Apr.

 https://advances.sciencemag.org/content/7/18/eabd2710

Copper promotes tumorigenesis by activating the PDK1-AKT oncogenic pathway in a copper transporter 1 dependent manner
Jianping Guo, Ji Cheng, Nana Zheng, Xiaomei Zhang, Xiaoming Dai, Linli Zhang, Changjiang Hu, Xueji Wu, Qiwei Jiang, Depei Wu, Hitoshi Okada, Pier Paolo Pandolfi, Wenyi Wei
Advanced Science 2021, 2004303

 https://onlinelibrary.wiley.com/doi/10.1002/advs.202004303

KDM4B promotes acute myeloid leukemia associated with AML-ETO by regulating chromatin accessibility
Takeshi Ueda*, Akinori Kanai, Akiyoshi Komuro, Hisayuki Amano, Kazushige Ota, Masahiko Honda, Masahito Kawazu, Hitoshi Okada* (*co-correspondence)
FASEB BioAdvances 29 August 2021. https://doi.org/10.1096/fba.2021-00030

 https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fba.2021-00030